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How do I administer injections for weight loss?

Learn how to safely use your weight loss pen and where to inject yourself

For those of you beginning your weight loss journey with the help of an injectable medicine, it is important to know how to correctly administer your medication.

The following article will walk you through using your injection pen safely, and inform where on your body you can administer it.

This information applies to Wegovy, and Saxenda injection pens.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 19-12-2024

How do I prepare my injection pen?

There are several steps to be taken to prepare your pen.

Here is a diagram of what your pen will look like. You can see the treatment through the pen window and scale.

There is a dose selector which you twist to find the correct dose. The dose button administers the treatment.

The pen is designed to be easy and accurate to use, so you can successfully administer the weight loss medication yourself.

1. Check the liquid

Always begin by checking the colour of the liquid inside your pen (this is visible through the pen window). The liquid should be clear and colourless.

If the liquid appears cloudy or coloured, do not use the injection pen as the medicine may be unsafe to take.

A weight loss pen with a clear, colourless liquid

Also, make sure to check:

  • that the label on the pen matches your weight loss treatment
  • for any signs of damage
  • that the medication is within its expiry date

2. Attach a needle

The first step to using your weight loss pen is to attach a needle. Remember, you must attach a brand new needle every time you inject yourself with the treatment.

Needles are packed with your order. They come inside 2 removable caps so you can safely attach them yourself.

To attach the needle, you need to:

  • remove the paper tab from the needle package
  • insert the needle directly onto the pen, screwing it on tightly
  • remove the outer and inner needle caps
  • keep hold of the biggest cap (to help with the removal process later on)
  • dispose of the other needle cap

3. Check the flow

Next, you must check the flow before taking your first dose. This ensures that the treatment will flow through the needle and into your body when injected.

You only need to check the flow when starting a new pen. These weight loss pens contain multiple doses and are reused - only the needle is replaced with every dose.

To check the flow of your pen, turn the dose selector until you reach the ‘flow check’ symbol. This will appear as two dotted lines and a dash.

Then hold the pen vertically, with the needle pointing upwards. Press and hold the button until the dose selector reaches 0 again.

You should see a drop of liquid on the needle. This means that the pen’s flow is working correctly.

4. Select your dose

Now that your pen is prepared, you must select your dose. For Wegovy you will begin on a dose of 0.25mg, and for Saxenda you will start on a 0.6mg dose.

Semaglutide dosages are increased every 4 weeks of treatment, and liraglutide dosages are increased weekly.

Rotate the dose selector until you see the right number appear on the pen. You may hear several clicks as you are turning.

Always take the dose that has been prescribed by your doctor. Exceeding this dose could result in adverse side effects such as nausea and vomiting.

Once you have selected the correct dose, you are ready to inject yourself.

Where can I inject myself?

When taking weight loss injections, the aim is to inject yourself subcutaneously (into fatty tissue just beneath the skin).

You can choose any of these 3 injection sites:

  • upper arm
  • stomach
  • upper thighs

Stick to the upper region of your thighs and do not inject within 2 inches of your belly button. You can also pinch the area to aid with injecting into the fatty tissue.

Over the weeks you can change your injection site or keep it the same. However, you must not:

  • inject yourself in the exact same spot more than once
  • inject any bruised, red, or damaged skin

How do I administer my injection?

Clean the injection site with an alcohol wipe, to sanitise the area.

To administer your injection, hold the pen in one hand and use your other hand to stretch your skin flat.

Lightly push the pen into your skin at a 90-degree angle so that the needle is no longer exposed.

Press the dose button and let the dose counter go back down to 0.

Keep holding the button while counting slowly to 6.

Finally, remove the needle from your skin.

It is unlikely that you will bleed from the injection site. If you see a drop of blood, apply some pressure with a clean tissue or cotton ball.

How do I remove the needle?

To remove the needle, place the outer needle cap back on the needle and click into place.

This allows you to unscrew both the cap and needle safely, before disposing of them.

Remember, you must use a brand new needle every time you inject yourself with weight loss treatment.

Where can I dispose of my used needles and pens?

Needles and pens must be disposed of in a special container called a sharps bin.

A yellow sharps disposal container

This is a specially designed box that safely stores any sharp items that are too dangerous to put in your general waste.

Once you fill your sharps bin, contact your local council and they should see to its removal. Otherwise, you can drop it off at a nearby waste disposal centre.

Main takeaways

The more you use your injection pen, the easier it will get. However, for those of you who are new to it, remember these 4 steps:

1) Prepare your pen 2) Choose your injection site
Make sure the liquid is clear and check the flow of your pen. Select your dose. Choose either the upper arm, stomach, or front of thigh as your injection site.
3) Administer your injection 4) Discard
Insert the needle at a 90-degree angle. Hold the button till the dose reaches 0, then count slowly to 6. Remove the needle by using the outer cap and dispose of in a yellow sharps container.

Further reading

Wegovy interactions: what you need to know

A guide to prescription weight loss treatments Wegovy interactions: what you need to know

Reviewed by Dr. Plauto Filho
5 ways to increase weight loss on Wegovy

A guide to prescription weight loss treatments 5 ways to increase weight loss on Wegovy

Reviewed by Dr. Plauto Filho
Ozempic weekly injection pen

A guide to prescription weight loss treatments Ozempic weekly injection pen

Reviewed by Dr. Plauto Filho
Side effects of Liraglutide and how to manage them

A guide to prescription weight loss treatments Side effects of Liraglutide and how to manage them

Reviewed by Dr. Plauto Filho
Semaglutide: what to expect and when

A guide to prescription weight loss treatments Semaglutide: what to expect and when

Reviewed by Dr. Plauto Filho
Semaglutide side effects: what you need to know

A guide to prescription weight loss treatments Semaglutide side effects: what you need to know

Reviewed by Dr. Plauto Filho
What semaglutide dose should I take?

A guide to prescription weight loss treatments What semaglutide dose should I take?

Reviewed by Dr. Plauto Filho
An introduction to GLP-1 agonists for weight loss

A guide to prescription weight loss treatments An introduction to GLP-1 agonists for weight loss

Reviewed by Dr. Plauto Filho
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