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A guide to prescription weight loss treatments

Losing weight on your own is never easy. Thankfully, you no longer have to. Numerous treatments are available that, when combined with a healthy lifestyle, help you reach your goals.

We’re discussing all of the available treatments and what to consider when choosing your treatment. Keep reading to learn more.

Medically reviewed by Dr. Plauto Filho Written by our editorial team Last reviewed 19-11-2024

Who can use prescription weight loss treatments?

Prescription weight loss treatment is only suitable if you are above a specific body mass index (BMI).

Close up of an overweight woman measuring her waist with tape measure.

To be prescribed a weight loss treatment, you must either:

  • have a BMI of 30 or above
  • OR have a BMI of 27 or above and have a weight-related condition

Weight-related conditions include type 2 diabetes, high blood pressure, and high cholesterol.

Consult your doctor if you're not sure whether you qualify.

What prescription weight loss treatments are available?

There are many factors to consider when determining which weight loss drug is best for you. Here is a helpful table showing all weight loss medications available and how they differ from each other.

Treatment Efficiency Potential Weight Loss How It Works Active Ingredient Usage Dosage Changes* Prices From:
Mounjaro Very high Up to 20% in 17 months Reduces appetite and increases energy use Tirzepatide Weekly injection Increases after 4 weeks £179.99
Wegovy High Up to 15% in 1 year Reduces appetite by slowing stomach emptying Semaglutide Weekly injection Increases monthly until month 4-5 £169.00
Saxenda Moderate Up to 11% in 1 year Reduces appetite by slowing stomach emptying Liraglutide Daily injection Increases weekly until reaching 3.0mg £69.99
Mysimba Moderate Up to 10% in 1 year Alters brain pathways to reduce appetite Bupropion & Naltrexone 1-4 tablets daily Increases weekly until week 4 £109.99
Xenical Moderate Up to 10% in 1 year Decreases fat absorption from food Orlistat Up to 3 capsules daily Remains the same £59.99

Deciding which treatment is right for you depends on many factors, but you don't have to make the decision alone. Start a consultation with HealthExpress today, and our doctors will assist you in selecting the appropriate treatment for your needs.

Mounjaro has shown remarkable results in clinical trials, making it a top choice for patients looking to achieve significant weight loss safely.

Dr. Anup JethwaClinical Lead

What are weight loss injections?

Injections are a new way to try to lose weight. They come as injection pens that you give yourself. You start with a small amount of the medicine and then you gradually take more of it over time.

 Close up of male hands holding an injection pen.

There are two weight loss injections available on the market: Wegovy and Saxenda. Wegovy contains the same active ingredient as Ozempic but has been licensed for weight loss (rather than diabetes). It is also available in higher doses.

They have been clinically proven to help with weight loss. Research has found patients lose upwards of 35 lbs after 15 weeks of use.

How do weight loss injections work?

Weight loss pens help you lose weight by reducing your appetite. They make your body create more of a hormone called glucagon-like peptide-1 (GLP-1). This hormone controls how hungry you feel.

Increasing the level of this hormone slows down your digestion and delays the stomach-emptying process. Doing so makes you feel fuller for longer and means you eat less. Over time, this results in fat loss.

What is Orlistat?

The final weight loss medication available in the UK is known as Orlistat. It is available under several brands, including Xenical and Alli.

It is available as a 120mg tablet that you take 3 times a day. In addition, it is the only treatment that is available over the counter at a lower dose (60mg).

How does Orlistat work?

It works differently from the other medications on the list in that it affects your digestive system. It decreases the amount of fat your body absorbs from your diet.

It is a lipase inhibitor; it stops the digestive enzyme lipase from breaking down dietary fat. This prevents fat from being used or stored for energy, which causes fat loss. Studies have shown Orlistat can reduce fat absorption by 30%.

The excess dietary fat then passes through your digestive system and leaves your body through your bowel movements.

What are the benefits of prescription weight loss pills and injections?

The main benefit of prescription treatment is that they are safe and regulated. Many herbal products claim to help you lose weight naturally and quickly. However, because they are not regulated, there is no guarantee they are safe or effective.

Assorted supplements on a wooden spoon.

Products that claim to burn fat quickly or slim your waist with just natural ingredients are most likely not very effective. This includes supplements, “slimming pills”, teas or other natural slimming products.

If you are buying any herbal products, always check with your doctor first, especially if you take any other medications or have other health conditions. If you are buying online, ensure the site is credible and run by registered healthcare professionals.

Do I need to change my lifestyle whilst on weight loss treatment?

The medications only do half of the work. They are a tool to help with weight loss and will not work as well without a healthy diet and exercise regime.

Young overweight women exercising in the gym.

Aim to eat a balanced and reduced-calorie diet. This involves reducing high-fat, processed and sugary foods. Try to incorporate more lean proteins and vegetables into your diet instead.

In terms of physical activity, you should aim for 150 minutes of moderate-intensity activity a week, such as a brisk walk or household chores. Alternatively, you could do 75 minutes of vigorous-intensity activity a week, such as jogging or cycling.

These positive lifestyle changes will not only help you reach a healthy weight, but they will also improve your health and well-being overall.

How do I get weight loss treatment?

If you are considering treatment, you should first consult your doctor. They will decide if it's right for you. Then, they will advise you on how to get treatment.

They may refer you to a specialist weight management clinic if you want treatment on the NHS. However, there is usually a waiting list. You can also buy Orlistat 60mg over the counter. Ask your pharmacist.

You can also get weight loss treatment privately from an online or in-person weight loss clinic.

Can I buy weight loss treatment online?

Yes, you can buy weight loss treatment online. However, you must ensure the website is reputable. The website should be approved by relevant health agencies and the staff must all be registered practitioners.

Get weight loss treatment online

Start your consult today

At HealthExpress, you can buy weight loss treatment online. All you have to do is complete an online consultation. Then our doctors will decide whether you are suitable for treatment. Once approved, your treatment will be delivered with free next-day delivery to your front door.

Our clinical team is registered with the GMC and GPhC, respectively. The CQC (Care Quality Commission) also regulates our service.

Further reading

Wegovy interactions: what you need to know

A guide to prescription weight loss treatments Wegovy interactions: what you need to know

Reviewed by Dr. Plauto Filho
5 ways to increase weight loss on Wegovy

A guide to prescription weight loss treatments 5 ways to increase weight loss on Wegovy

Reviewed by Dr. Plauto Filho
Ozempic weekly injection pen

A guide to prescription weight loss treatments Ozempic weekly injection pen

Reviewed by Dr. Plauto Filho
Side effects of Liraglutide and how to manage them

A guide to prescription weight loss treatments Side effects of Liraglutide and how to manage them

Reviewed by Dr. Plauto Filho
Semaglutide: what to expect and when

A guide to prescription weight loss treatments Semaglutide: what to expect and when

Reviewed by Dr. Plauto Filho
Semaglutide side effects: what you need to know

A guide to prescription weight loss treatments Semaglutide side effects: what you need to know

Reviewed by Dr. Plauto Filho
What semaglutide dose should I take?

A guide to prescription weight loss treatments What semaglutide dose should I take?

Reviewed by Dr. Plauto Filho
An introduction to GLP-1 agonists for weight loss

A guide to prescription weight loss treatments An introduction to GLP-1 agonists for weight loss

Reviewed by Dr. Plauto Filho
How do I administer injections for weight loss?

A guide to prescription weight loss treatments How do I administer injections for weight loss?

Reviewed by Dr. Caroline Fontana
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